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Leading bulk Producers of "withaferin A" "Now avilable in all quantities up to 1000 grams level"
 
 
 
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List of Phytochemicals with Activity

Withaferin A
Bulk Phytochemicals:
  1. Withaferin A
  2. Corosolic acid
  3. 3-Acetyl-11-keto beta boswellic acid
  4. Nicergoline

Withaferin A  
Synonym 5,6-Epoxy-4,27-dihydroxy-1-oxo witha-2,24-dienolide
Product Specification      
 
Source/Host : Withania somnifera
Appearance : White to off-white solid
CAS No. : 5119-48-2
Linear Formula :C28H38O6
Molecular Weight : 470.60
Assay :>95% (HPLC)
Applications :Withaferin A has shown significant anticancer activity in animal studies.
Structure :
Quantities Available : 1 gram to 100 grams
References:
1. Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves: B. Jayaprakasam, et al.; Life Sci. 74, 125 (2003)
2.Withaferin A is a potent inhibitor of angiogenesis: R. Mohan, et al.; Angiogenesis 7, 115 (2004)
3.Neuritic regeneration and synaptic reconstruction induced by withanolide: A: T. Kuboyama, et al.; Br. J. Pharmacol. 144, 961 (2005)
4.Actin microfilament aggregation induced by withaferin A is mediated by annexin II: R.R. Falsey, et al.; Nat. Chem. Biol. 2, 33 (2006)
5.Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity: M. Kaileh, et al.; J. Biol. Chem. 282, 4253 (2007)
6.The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin: P. Bargagna-Mohan, et al.; Chem. Biol. 14, 623 (2007)
 
Corosolic acid  
Synonym 2-alpha Hydroxy Ursolic acid
(2a,3b)-2,3-Dihydroxy-urs-12-en-28- oic acid
Product Specification      
 
Source/Host : Lagerstroemia speciosa (Banaba)
CAS No. : 4547-24-4
Linear Formula : C30H48O4
Molecular Weight : 472.70
Assay : >95% (HPLC)
Applications : Corosolic acid has numerous biological properties including anti diabetic, anti inflammatory, anti proliferative and protein kinase C inhibition activity.
Structure :
Quantities Available : 1 gram to 100 grams
 
3-O-Acetyl-11-keto beta boswellic acid
Synonym AKBA
Product Specification      
 
Source/Host : Boswellia serrata
CAS No. : 67416-61-9
Linear Formula : C32H48O5
Molecular Weight : 512.70
Assay : >95% (HPLC)
Applications : Shows antitumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-times more potent than 3-O-acetyl--boswellic acid
Structure :
Quantities Available : 10 gram to 10 Kilograms
 
Nicergoline
Synonym 5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester
Product Specification      
 
Source/Host : Semi synthetic
CAS No. : 27848-84-6
Linear Formula : C24H26BrN3O3
Molecular Weight : 484.39
Assay : >97 %
Applications : ?-adrenergic, vasodilator. Cognitive enhancer.
Structure :
Quantities Available : 1 gram to 1000 grams
References:
1. Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats: Chopin and Brile.; Psychopharmacology 106, 26 (1992)
2. Modulation of hippocampal ACh release by chronic nicergoline treatment in freely moving young and aged rats: Carfagna et a.; Neurosci.Lett. 197, 195(1995)
 
 
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